Apoptosis induced by cannabis can potentially cure cancer in animal studies. Why has there been no human studies?

There are several reasons why there have been limited human studies on the ability of cannabis to induce apoptosis in cancer cells and cure cancer. Some of these reasons include:

1. Regulatory barriers: Conducting human studies with cannabis is complex and requires approval from various regulatory agencies, including the Food and Drug Administration (FDA) and the Drug Enforcement Administration (DEA). The classification of cannabis as a Schedule I substance under the Controlled Substances Act has made it difficult to obtain the necessary approvals to conduct clinical trials.

2. Limited funding: Clinical trials are expensive and require significant funding, which has been a challenge in the case of cannabis-related research, particularly given the Schedule I classification of the substance and the stigma associated with its use.

3. Lack of standardization: The composition of cannabis-based products can vary widely, which makes it difficult to conduct clinical trials that accurately reflect the effects of specific compounds found in cannabis.

4. Unclear mechanism of action: The mechanisms by which compounds found in cannabis induce apoptosis in cancer cells are not yet fully understood, and more research is needed to determine the most effective dose, route of administration, and combination of compounds that would be most effective in treating cancer.

Despite these challenges, there has been some progress in recent years towards conducting human trials on the therapeutic potential of cannabis for cancer. For example, a few small-scale clinical trials have been conducted to evaluate the safety and efficacy of cannabis-based treatments for symptoms related to cancer treatment, such as pain, nausea, and loss of appetite. However, much more research is needed to fully understand the potential of cannabis as a treatment for cancer in humans.